4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine

4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine - Names and Identifiers

Name	4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
Synonyms	LogP 4-chloro-6-iodo-7H-pyrrolo[2 4-Chloro-6-iodo-7H-pyrrol... 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine 4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine 4-chloro-6-iodo-1H-pyrrolo[2,3-d]pyrimidine 7H-Pyrrolo[2,3-d]pyrimidine, 4-chloro-6-iodo- 7H-pyrrolo[2,3-d]pyrimidine, 4-chloro-6-iodo-
CAS	876343-10-1
InChI	InChI=1/C6H3ClIN3/c7-5-3-1-4(8)11-6(3)10-2-9-5/h1-2H,(H,9,10,11)

4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine - Physico-chemical Properties

Molecular Formula	C6H3ClIN3
Molar Mass	279.47
Density	2.284±0.06 g/cm3(Predicted)
pKa	9.74±0.50(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.804

4-Chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine - Introduction

[2,3-d]pyrimidine is an organic compound with the formula C6H2ClIN4. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: Colorless or yellowish solid.
-Melting point: approximately 200-208°C.
-Solubility: Soluble in some organic solvents, such as chloroform, dichloromethane and dimethyl sulfoxide.

Use:
-[2,3-d]pyrimidine is an important organic synthesis intermediate, which has a wide range of applications in the pharmaceutical, pesticide and dye industries.
-It can be used as a raw material for the synthesis of other organic compounds, such as pyrrolo [2,3-D] pyrimidine anticancer drugs.

Preparation Method:
[2,3-d] The preparation method of pyrimidine is relatively complicated, and it is generally synthesized using a multi-step reaction. The following is a common synthesis method:
-First, 4-iodoaniline was synthesized by reacting iodobenzene and triethylamine in chloroform.
-Then, 4-iodoaniline and 3-aminopyrrolo [2,3-D] pyrimidine are condensed at a certain temperature and reaction conditions to obtain 4-aminopyrrolo [2,3-d]pyrimidine.

Safety Information:
-[2,3-d]pyrimidine may cause irritation and damage to the human body, and may be harmful to the environment.
-Appropriate personal protective measures, such as wearing protective gloves, goggles and respiratory protection, should be taken when using and handling the compound.
-It should be stored in a closed container, away from fire and oxidizing agents.
-During handling and handling, the safe handling of chemicals should be observed.

Last Update：2024-04-09 21:01:54